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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDC5L
All Species:
14.24
Human Site:
T614
Identified Species:
26.11
UniProt:
Q99459
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99459
NP_001244.1
802
92251
T614
T
N
N
S
E
H
I
T
Y
L
E
H
N
P
Y
Chimpanzee
Pan troglodytes
XP_518512
698
80173
K532
P
P
L
T
D
L
Q
K
S
E
E
L
I
K
K
Rhesus Macaque
Macaca mulatta
XP_001100220
802
92232
T614
T
N
N
S
E
H
I
T
Y
L
E
H
N
P
Y
Dog
Lupus familis
XP_532156
908
104015
A720
T
N
N
S
E
H
I
A
Y
L
E
H
N
P
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q6A068
802
92171
T614
T
N
N
S
E
H
I
T
Y
L
E
H
S
P
Y
Rat
Rattus norvegicus
O08837
802
92199
T614
T
N
N
S
E
H
I
T
Y
L
E
H
S
P
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511089
803
92142
V614
G
T
N
S
T
E
H
V
T
Y
L
E
S
T
P
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_957378
800
91707
L614
N
A
E
H
I
S
Y
L
E
K
T
P
Y
E
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624906
781
89377
P603
Q
A
Y
L
E
Q
H
P
Y
I
N
F
E
K
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001178584
701
79489
R538
E
E
R
E
K
E
L
R
S
R
S
Q
S
L
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92948
844
95748
L620
N
R
S
A
S
Q
V
L
A
I
D
D
F
D
E
Baker's Yeast
Sacchar. cerevisiae
Q03654
590
67712
T437
A
V
P
L
A
Y
S
T
L
P
I
P
E
F
K
Red Bread Mold
Neurospora crassa
Q7SAF6
779
87489
A583
R
E
A
A
L
L
V
A
H
D
A
T
K
Y
P
Conservation
Percent
Protein Identity:
100
86.4
99.7
87.4
N.A.
98
97.8
N.A.
93.9
N.A.
N.A.
84
N.A.
N.A.
63.9
N.A.
58.2
Protein Similarity:
100
86.6
100
88.2
N.A.
99.1
99.2
N.A.
97.6
N.A.
N.A.
92.3
N.A.
N.A.
77
N.A.
70.2
P-Site Identity:
100
6.6
100
93.3
N.A.
93.3
93.3
N.A.
13.3
N.A.
N.A.
0
N.A.
N.A.
13.3
N.A.
0
P-Site Similarity:
100
20
100
93.3
N.A.
100
100
N.A.
20
N.A.
N.A.
0
N.A.
N.A.
20
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
44.6
31.4
44.3
Protein Similarity:
N.A.
N.A.
N.A.
63
46.6
60.7
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
0
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
13.3
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
16
8
16
8
0
0
16
8
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
0
0
0
0
8
8
8
0
8
0
% D
% Glu:
8
16
8
8
47
16
0
0
8
8
47
8
16
8
16
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
8
8
8
0
% F
% Gly:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
8
0
39
16
0
8
0
0
39
0
0
0
% H
% Ile:
0
0
0
0
8
0
39
0
0
16
8
0
8
0
0
% I
% Lys:
0
0
0
0
8
0
0
8
0
8
0
0
8
16
24
% K
% Leu:
0
0
8
16
8
16
8
16
8
39
8
8
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
16
39
47
0
0
0
0
0
0
0
8
0
24
0
0
% N
% Pro:
8
8
8
0
0
0
0
8
0
8
0
16
0
39
16
% P
% Gln:
8
0
0
0
0
16
8
0
0
0
0
8
0
0
8
% Q
% Arg:
8
8
8
0
0
0
0
8
0
8
0
0
0
0
0
% R
% Ser:
0
0
8
47
8
8
8
0
16
0
8
0
31
0
0
% S
% Thr:
39
8
0
8
8
0
0
39
8
0
8
8
0
8
0
% T
% Val:
0
8
0
0
0
0
16
8
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
8
8
0
47
8
0
0
8
8
39
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _